Encap-X®Nanoparticle encapsulation system

Reproducible and scalable production of lipid nanoparticles ​Request information


EncapX® is an automated, continuous supercritical CO₂–based platform designed for the reproducible and scalable production of lipid nanoparticles and nanoliposomes.

It overcomes the limitations of conventional microfluidic and solvent-based encapsulation methods through a patented millifluidic supercritical CO₂ process, enabling precise control of nanoparticle formation while reducing solvent usage and eliminating clogging issues.

EncapX® is suitable for R&D, preclinical development, and industrial-scale manufacturing, with a design compatible with GMP environments.

Current limitations of nanoparticle formulation methods


Conventional nanoparticle formulation techniques often face critical limitations: 

  • Uncontrolled particle size 
  • Clogging issues
  • Limited reproducibility
  • Poorly scalable

These constraints slow down development timelines and increase operational costs.

EncapX: a new generation encapsulation platform

  • Precision & stability: delivers exceptionally uniform particles 
  • High encapsulation efficiency (> 97%)
  • High Productivity: no clogging issues, ensuring  continuous, scalable, and automated production with low OPEX.
  • From R&D to industrial use
  • Gentle Processing: Operates at a low temperature(35 °C), preserving the integrity of heat-sensitive APls like enzymes, probiotics, and mRNA.
  • GMP-compatible design
  • Eco-Designed: A 100% non toxic solvent - free process with no residues or harmful emissions.

Technical specifications​


  • Nano to micro (application-dependent)
  • Nanoparticle size range: ~60–150 nm 
  • Narrow size distribution (+/- 3%)
  • Compatible with liposomes & lipid nanoparticles (LNPs)
  • Suitable for sensitive APIs (RNA, mRNA, proteins, antibodies, peptides, small molecules)
  • Automated and controlled operating parameters
  • Scalable flow rates

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  • Robust millifluidic design (no clogging)
  • Operating mode: Continuous
  • Automation: Fully automated
  • Scale: R&D to industrial, GMP-compatible design
  • Control parameters: Pressure, temperature, flow rates


EncapX® relies on a patented millifluidic process using supercritical CO₂

Application & uses cases


  • Pharmaceuticals: Stabilizing unstable molecules for anticancer therapies and new mRNA treatments (e.g. overcoming the -80°C storage challenge for some vaccines)
  • Cosmetics: Protecting vitamins and antioxidants from oxidation. 
  • Nutraceuticals: delivering sensitive compounds like DHA and natural pigments effectively


SCIENTIFIC BACKGROUND : go to  /scientific-publications

Discuss your formulation challenges


EncapX® is available as an industrial encapsulation system.


Prior to equipment deployment, Biotech One can also support feasibility studies, process optimization, and pilot-scale production to assess formulation performance and scalability.


We additionally offer limited production of encapsulated ingredients or demonstration batches, depending on project scope and regulatory context.

📩 Contact us to discuss your formulation challenges, technical requirements, or project feasibility.