Sc CO2 Encapsulation

Sustained release delivery system

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Encapsulation is crucial on formulation process

Need to protect and release valuable compounds

Limitation with current encapsulation process

  • Current processes require organic solvents
  • Require removal residual solvents for pure extract
  • High Temperature can be required (above 50°C)
  • Need separation steps

Limitation with current encapsulation equipment 

  • Microfluidique technology: particle size > 5000 nm
  • Maintain issue: clogging on vessels

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Sc CO2 solution

We develop an innovative technology and equipment solution for nanoformulation

  • No waste, no residue, no solvent, non toxic
  • Better unimodal size/population distribution
  • Obtain precise control over encapsulation
  • More homogeneous and optimal properties (APIs) 
  • Enhancing product stability and bioavailability
  • Faster and compact process (no need separation steps)
  • Particle size >60 nm (vs microfluidique > 5000 nm)
  • Reduced process time (5 to 10 times)
  • Reduced operation cost (from to 2 to 4 times)

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Market applications

Cosmetics, Nutraceuticals, Food, Pharma, Biotech

  • Cosmetics ingredients with optimal properties
  • Encapsulation of fragrances in deodorants
  • Stabilized natural pigments used in lipstick formulations to improve shelf life.
  • Nutraceuticals: plant extracts, Magnesium, Fe, can be encapsulated to mask their taste
  • Encapsulated peptides for triggered release in the intestines
  • Food: controlled release systems developed for enzymes
  • Pharma APIs (Active Pharmaceutical Ingredients): increased shelf life (from 5 to 10 times) through encapsulation
  • Enhanced stability and bioavailability of pharmaceutical products, reducing the required amount of active ingredient
  • Intelligent nanosystems (cancer therapy, gene therapy)
  • RNA & DNA vaccines 

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Competitive advantages

CO2 above a certain temperature and pressure (*)

offers the advantages of both a gas and a liquid:


  • Zero waste, no residue, no solvent. Nontoxic


  • Low T° (32°C): heat-sensitive products
  • (currently solvent often T° > 60°C)
  • Minimizes risk of thermal/chemical degradation
  • Penetrating power (density of a liquid, diffusivity of a gas)
  • Better unimodal size/population distribution
  • Obtain precise control over encapsulation
  • Avoids formation of unwanted by-products
  • Better control of product properties (encapsulation)
  • Biocidal properties of CO2 (sterilization)
  • More homogeneous and optimal properties (APIs) 
  • Enhancing product stability and bioavailability
  • Particle size >60 nm (vs microfluidique > 5000 nm)


  • Faster and compact process (no need separation steps)
  • Reduced process time (5 to 10 times)
  • Reduced operation cost (from to 2 to 4 times)
  • Compact, modular and integrated process

(*) Tc=31°C, PC=73,8 bar

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How does it work ?

CO2 encapsulation involves enclosing an active compound (solid, liquid, or gas) within a coating material. The active compound forms the inner core, which is then enveloped by a capsule material.

The choice of coating materials depends on the desired application and can be selected from a variety of natural or synthetic options.  We can use different types of coated particles for triggered release: mononuclear, polynuclear, or matrix-like.

CO2 serves as an ideal inert medium for preserving sensitive actives during processing (low temperatures process).

CO2 encapsulation is a one-step process that can be performed batch-wise or continuously. The resulting encapsulates are ready for use without any additional treatment.

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    • Contract Research Service: Feasibility, optimization, scale-up
    • Patent licensing and co-development
    • Production 

    To further expand our impact, we are actively seeking partnerships for collaborative development initiatives. 

    Join us in exploring co-developing innovative solutions that drive progress in the industry.

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    Patent Licencing


    • Extraction of compounds from microalgae (continuous process, no drying step)
    • Sterilization with pouches or blisters
    • Encapsulation using nanoliposomes or LNPs (process and equipment patent)

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    Providing a Global Alternative Solution

    After conducting successful feasibility and scale-up studies, we offers the following services:

    1. Scalable Modular Unit Design: we assist in dimensioning scalable modular units tailored to your specific needs.
    2. Implementation of  Units: We support the implementation of units based on the outcomes of our studies.
    3. Financial Intervention and Co-Financing: we can provide financial support or co-finance projects, offering different legal structures such as dedicated subsidiaries.
    4. Pilot Testing and Production: Leveraging ScCO2 technology, we specialize in extraction, particle generation, encapsulation of compounds and sterilization processes.

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    Reduce OPEX & CAPEX

    Optimizing Engineering Techniques for Cost-effective Results

    Our engineering techniques prioritize minimizing pressure, process volume, flow, and time in CO2 extraction to reduce operational (OPEX) and capital expenditures (CAPEX). However, it is crucial to balance these parameters with product yield and quality. The combination of product quality, yield, and costs determines the economic viability of our process.

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    Enhancing the stability and bioavailability of formulations