Sustained release delivery system

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Impregnation is the opposite process of extraction

Impregnation is a process of saturating materials with components by dissolving a pure compound in a solvent like water or CO2, and then exposing the material to the enriched solvent. 

Overcoming challenges:

  • Careful substance selection and parameter optimization
  • Consideration of material properties
  • Development of tailored techniques or technologies

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Sc CO2 solution

Advantages of carbon dioxide

  • Sc CO2 is often used due to its properties
  • High diffusivity
  • Low surface tension
  • Easy removal
  • The amount of compound attached to the material depends on its affinity to the compound
  • Cost-effective supercritical process
  • No waste, no residue, no solvent, non toxic

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Market applications

Medtech, Medical Device, Tissue Engineering

  • Supercritical Impregnation can be used in textile dyeing, coating of substrates, impregnations of actives on substrate for medical application, etc.

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Competitive advantages

CO2 above a certain temperature and pressure (*)

offers the advantages of both a gas and a liquid:


  • Zero waste, no residue, no solvent. Nontoxic


  • Low T° (32°C): heat-sensitive products
  • (currently solvent often T° > 60°C)
  • Minimizes risk of thermal/chemical degradation
  • Penetrating power (density of a liquid, diffusivity of a gas)
  • Better unimodal size/population distribution
  • Obtain precise control over encapsulation
  • Avoids formation of unwanted by-products
  • Better control of product properties (encapsulation)
  • Biocidal properties of CO2 (sterilization)
  • More homogeneous and optimal properties (APIs) 
  • Enhancing product stability and bioavailability
  • Particle size >60 nm (vs microfluidique > 5000 nm)


  • Faster and compact process (no need separation steps)
  • Reduced process time (5 to 10 times)
  • Reduced operation cost (from to 2 to 4 times)
  • Compact, modular and integrated process

(*) Tc=31°C, PC=73,8 bar

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How does it work ?

The Sc CO2 micronization process offers several advantages, including the ability to produce fine particles with controlled size distributions, minimal risk of contamination, and preservation of the material's integrity. It is widely used in industries such as pharmaceuticals, food processing, cosmetics, and nanotechnology for achieving precise particle size reduction and improving product performance.

During micronization, fats, oils, or waxes are mixed with carbon dioxide, leading to solidification and the formation of a powdered product with altered crystallinity and increased surface area.

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    • Contract Research Service: Feasibility, optimization, scale-up
    • Patent licensing and co-development
    • Production 

    To further expand our impact, we are actively seeking partnerships for collaborative development initiatives. 

    Join us in exploring co-developing innovative solutions that drive progress in the industry.

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    Unleash the Power of Surface Area in Creams and Spreads